关键词: 婴儿, 早产, 疾病, 晚期早产儿, 婴儿, 小于胎龄, 呼吸系统并发症, 危险因素

Abstract: Background　The physical development of small-for-gestational-age（SGA） infants is poorer than that of appropriate-for-gestational-age（AGA） infants，and they are prone to complications such as respiratory distress syndrome，pulmonary infection，feeding intolerance，cerebral palsy，growth and development retardation.In particular，late preterm SGA infants are more susceptible to respiratory diseases.However，there are relatively few studies on the risk factors of perinatal respiratory complications in late preterm SGA infants.Objective　To investigate the occurrence and risk factors of perinatal respiratory complications in late preterm SGA infants.Methods　A retrospective analysis was conducted on the clinical data of late preterm infants（n=100）admitted to the First Affiliated Hospital of Hebei North University from January 2015 to January 2017 except large-for-gestational-age infants.They were then divided into SGA infants（n=45）and AGA infants（n=55）based on birth weight and were compared in terms of perinatal respiratory complications incidence.Univariate analysis was used to screen maternal and infant-related factors possibly associated with infant respiratory complications by comparing SGA infants with respiratory complications（n=28）and those without（n=17），and the identified high-risk factors were further analyzed with multivariate Logistic regression.Results　The incidence of perinatal respiratory complications in SGA infants was significantly higher than that of AGA infants（62.2% vs. 41.8%，χ2=4.122，P<0.05）.SGA infants with respiratory complications had higher prevalence of maternal-related factors associated with infant respiratory complications，including pregnancy-induced hypertension，multiple pregnancy，umbilical cord abnormalities，intrauterine distress，late pregnancy fever，premature rupture of membranes，history of asphyxia，and placental abruption，and higher prevalence of neonatal sepsis compared with those（P<0.05）.Multivariate Logistic regression analysis showed that pregnancy-induced hypertension，multiple pregnancy，infection during pregnancy，umbilical cord abnormalities，intrauterine distress，late pregnancy fever，premature rupture of fetal membranes，history of asphyxia，and neonatal sepsis were significantly associated with perinatal respiratory complications in late preterm SGA infants（P<0.05）.Conclusion　 Late preterm SGA infants may have higher incidence of perinatal respiratory complications than late preterm AGA infants，which may be closely associated with maternal pregnancy-induced hypertension，multiple pregnancy，infection during pregnancy，umbilical cord abnormalities，intrauterine distress，late pregnancy fever，premature rupture of membranes，history of asphyxia，and neonatal sepsis.

Key words: Infant, premature, diseases；Late preterm infants；Infant, small for gestational age；Respiratory complications；Risk factors