关键词: 结直肠肿瘤, 家庭主要照顾者, 亲密关系, 生活质量, 主体-客体互倚模型

Abstract: Background　The data showed that the situation for colorectal cancer prevention and control is severe in China in 2019.As cancer patients and their primary family caregivers are closely associated，they adapt to the influence of cancer together.So cancer and related treatment can impair the quality of life in the patients as well as that of their intimate primary family caregivers.Objective　To analyze the changes in quality of life of colorectal cancer patients and their primary family caregivers influenced by intimate patient-caregiver relationship based on actor-partner interdependence model（APIM），to provide a theoretical basis for delivering clinical interventions.Methods　By use of convenience sampling，colorectal cancer patients treated in Nanfang Hospital，Yunnan Cancer Hospital，the Sixth Affiliated Hospital，Sun Yat-sen University and their primary family caregivers were enrolled during November 2018 to May 2019.Patients and their caregivers received a self-administered survey separately with the Relationship Assessment Scale（RAS） and the Chinese version of 12-item Short-Form Health Survey（SF-12-C） for collecting their subjective satisfaction with the patient-caregiver relationship，and their self-rated quality of life in the past 7 days.An APIM was established based on the survey results and was used to analyze the changes of quality of life in both groups influenced by intergroup intimate relationship.Results　A total of 296 patient-caregiver dyads participated in the survey，and 271 of them gave responsive questionnaires，achieving a response rate of 91.6%.According to the survey，the RAS score of the patients was positively correlated with the caregivers' scores of RAS，Physical Component Summary（PCS） and Mental Component Summary（MCS）（P<0.05）.The PCS score of the patients was positively correlated with the caregivers' scores of PCS and MCS（P<0.05）.The MCS score of the patients was positively correlated with the caregivers' MCS score（P<0.05）.APIM-based analysis showed that，in terms of actor-effect，the RAS score of caregivers was positively correlated with their MCS score（P<0.001）.In terms of partner-effect，the RAS score of the patients was positively correlated with the PCS score of caregivers（P<0.001）.And the RAS score of caregivers was positively correlated with the PCS score of patients（P<0.001）.Conclusion　The RAS score of the colorectal cancer patients may positively associated with the quality of life of their primary family caregivers，while the RAS score of the caregivers may positively associated with the quality of life of themselves as well as that of the patients.

Key words: Colorectal neoplasms, Primary family caregivers, Intimate relationship, Quality of life, Actor-partner interdependence model