维生素D缺乏与妊娠期糖尿病及其母婴结局研究进展

doi:10.12114/j.issn.1007-9572.2019.00.138

摘要/Abstract

摘要： 妊娠期糖尿病可导致母婴不良结局，近年来我国妊娠期糖尿病发病率不断上升。维生素D可改善胰岛素敏感性和葡萄糖耐量，多项研究表明维生素D缺乏与妊娠期糖尿病风险增加有关，但是仍有部分研究结果与此相反。且目前研究多为观察性研究，随机对照试验数据有限，补充维生素D能否预防妊娠期糖尿病发生尚无定论。本文系统回顾了维生素D缺乏与妊娠期糖尿病发生风险的关系，同时就补充维生素D能否预防妊娠期糖尿病、改善妊娠期糖尿病患者糖脂代谢状态和母婴结局做一综述。

关键词: 维生素D缺乏；糖尿病, 妊娠；胰岛素抵抗；婴儿, 新生；综述

Abstract: Gestational diabetes can lead to adverse outcomes in mothers and babies.In recent years，the incidence of gestational diabetes in China has been rising.Vitamin D can improve insulin sensitivity and glucose tolerance，and many studies have shown that vitamin D deficiency is associated with an increased risk of gestational diabetes，while some studies have the opposite conclusion.In addition，most of the studies are observational studies，with few randomized controlled trials.Whether vitamin D supplementation can prevent gestational diabetes is still inconclusive.This article systematically reviewed the risk of vitamin D deficiency and gestational diabetes，and reviewed whether vitamin D supplementation can prevent gestational diabetes，improve glycolipid metabolism and maternal and fetal outcomes in patients with gestational diabetes.

Key words: Vitamin D deficiency；Diabetes, gestational；Insulin antibodies；Infant, newborn；Review

周芳,厉平. 维生素D缺乏与妊娠期糖尿病及其母婴结局研究进展[J]. 中国全科医学, 2019, 22(29): 3533-3538. DOI: 10.12114/j.issn.1007-9572.2019.00.138.
ZHOU Fang,LI Ping. Vitamin D Deficiency，Gestational Diabetes Mellitus and Its Maternal and Fetal Outcomes　[J]. Chinese General Practice, 2019, 22(29): 3533-3538. DOI: 10.12114/j.issn.1007-9572.2019.00.138.

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