关键词: 动脉粥样硬化, 复方丹参滴丸, 阿托伐他汀, 正五聚蛋白3, 血脂异常, 血管内皮

Abstract: Background　Carotid atherosclerosis is a local manifestation of systemic atherosclerosis.Active and effective preventive measures can effectively reduce the incidence of ischemic cardiovascular and cerebrovascular diseases.Atorvastatin calcium tablet can delay the development of atherosclerotic plaques by lowering lipid，but the effect is slow.In recent years，Chinese Traditional Medicine has been widely used in the treatment of cardiovascular and cerebrovascular diseases.Clinical study on the efficacy of compound danshen dropping pills combined with atorvastatin in the treatment of atherosclerosis is not very in-depth.Objective　To explore the effects of compound danshen dropping pill combined with atorvastatin on plasma pentraxin 3（PTX3） and related indexes of carotid atherosclerotic plaques in patients with carotid atherosclerosis（CAS）．Methods　According to the random number table，156 patients with CAS admitted to Harrison International Peace Hospital from March 2016 to February 2018 were divided into control group and research group，with 78 cases in each group.Patients in the control group were given atorvastatin calcium orally，two tablets/time，one time/day，while those in the research group with compound danshen dripping pill，10 pills/time，three times/day，on the basis of treatment in the control group.The course of treatment was two weeks.The clinical efficacy of the patients after treatment was counted.The levels of PTX3，blood lipid〔total cholesterol（TC），triglyceride（TG），low density lipoprotein cholesterol（LDL-C） and high density lipoprotein cholesterol（HDL-C）〕，endothelial function〔nitric oxide（NO） and vascular endothelin 1（ET-1），soluble intercellular adhesion molecule-1（sICAM-1），thromboxane B2（TXB2）〕 and carotid artery color Doppler flow imaging〔carotid intima-media thickness（IMT），carotid artery diameter（CAD） and carotid atherosclerosis plaque area（CASPA） and integral〕 were detected before and after the treatment.The occurrence of adverse reactions was also observed.Results　The clinical efficacy of the research group was significantly higher than that of the control group（u=2.020，P=0.043）．Compared with indicators before treatment，the levels of plasma PTX3，TC，TG and LDL-C significantly decreased in the two groups after treatment（P<0.05），while HDL-C level significantly increased（P<0.05）．After treatment，the serum NO level in two groups was significantly higher than that before treatment（P<0.05），while the levels of serum ET-1，sICAM-1 and TXB2 were significantly lower than those before treatment（P<0.05）．The IMT，CAD，CASPA and plaque integral in both groups after treatment were significantly lower than those before treatment（P<0.05）．No adverse reactions were observed in all patients during treatment.There was no significant change in liver and kidney function indexes.Conclusion　Compound danshen dripping pill combined with atorvastatin can not only effectively improve the plasma PTX3 level in CAS patients，but also stabilize blood lipids，vascular endothelial function and plaque parameters.As being safe as well.

Key words: Atherosclerosis, Compound danshen dropping pill, Atorvastatin, Pentraxins3, Dyslipidemias, Vascular endothelium