关键词: 糖尿病, 2型；代谢综合征X；发病年龄；超重；肥胖症；高血压；高甘油三酯血症；低高密度脂蛋白胆固醇血症

Abstract: Background　Diabetes is an important component of the metabolic syndrome（MS），which often combines with other metabolic components of MS.China's young and elderly diabetic patients are increasing year by year，but there is still a lack of studies on relationship of the age of onset of diabetes with MS and its components.Objective　To investigate the relationship of the age of onset of newly diagnosed type 2 diabetes（T2DM） with MS and other metabolic components of MS.Methods　431 patients with newly diagnosed T2DM were selected from Department of Endocrinology，Zhongnan Hospital of Wuhan University from January 2012 to May 2017.According to the age of onset，they were divided into early-onset diabetes group（EDM group，<40 years，n=72），middle-aged diabetes group（MDM group，40-59 years，n=232） and elderly diabetes group（ODM group，≥60 years，n=127）．The metabolic components of MS and MS in three groups were compared.Results　The prevalence rates of MS in all the newly diagnosed T2DM cases，EDM group，MDM group，and ODM group were 72.4%（312/431），79.2%（57/72），74.1%（172/232），and 65.4%（83/127），respectively.With the increase of onset age，the prevalence rate of MS in newly diagnosed patients with T2DM decreased（P<0.05）．Early onset age was associated with higher prevalence rates of overweight/obesity，elevated TG，decreased HDL-C and lower prevalence rate of hypertension（P<0.05）．There were statistical differences between the three groups（P<0.05）.The difference was between EDM and ODM（P<0.016 7）, but there was no difference between EDM and MDM，MDM and ODM（P>0.016 7）．Conclusion　The age of onset of newly diagnosed T2DM was closely related to MS，and the earlier the age of onset，the higher the risk of MS.

Key words: Diabetes mellitus, type 2；Metabolic syndrome X；Age of onset；Overweight；Obesity；Hypertension；Hypertriglyceridemia；Low high-density lipoprotein cholesterol