关键词: 糖尿病前期, 糖尿病, 高三酰甘油血症, 甘油三酯类, 腰围, 临床特征

Abstract: Background　In recent years，the incidence of pre-diabetes and diabetes in China has increased year by year.But the incidence may be reduced by early detection of related risk factors and timely interventions.The relationship of hypertriglyceridemic waist phenotype（HTGW）and blood sugar has not yet been determined.Objective　To explore the relationship of HTGW with pre-diabetes and diabetes mellitus.Methods　 By use of multi-stage stratified cluster random sampling，2 142 community-dwelling residents aged 18-75 years were recruited from Wanchai Town，Xiangzhou District，Zhuhai City，from June to October 2012.By waist circumference（WC）and serum triglyceride（TG）level，they were stratified into three groups：group 1（WC≤90 cm in males or ≤85 cm in females with TG<2.0 mmol/L），group 2（WC≤90 cm in males or ≤85 cm in females with TG ≥2.0 mmol/L，WC>90 cm in males or >85 cm in females with TG<2.0 mmol/L），group 3（WC>90 cm in males or>85 cm in females with TG≥2.0 mmol/L）．Clinical features were compared between the three groups.The relationship of HTGW with pre-diabetes and diabetes mellitus was analyzed by Logistic regression.Results　 Of the 2 142 participants, 169 were excluded because of lacking data of triglyceride or waist circumference. Finally, 1 973 participants were enrolled, including 172 patients with diabetes and 143 patients with prediabetes. And 1 141 patients were in the group 1; 624 patients were in the group 2; and 208 patients were in the group 3.Compared with group 1，group 2 showed higher mean age，male ratio，rates of hypertension，pre-diabetes，diabetes mellitus，and drinking，mean systolic blood pressure（SBP），diastolic blood pressure（DBP），BMI，fasting blood glucose（FBG），C-reactive protein（CRP），total cholesterol（TC），TG，low-density lipoprotein cholesterol（LDL-C），serum creatinine（Scr），and serum uric acid，and longer mean WC，but lower percent of completing high school or higher levels of education，and lower mean high-density lipoprotein cholesterol（HDL-C）（P<0.05）．In comparison with groups 1 and 2，group 3 demonstrated higher mean age，rates of hypertension，pre-diabetes，diabetes mellitus，smoking，and drinking，SBP，BMI，FBG，TC，TG，Scr，and serum uric acid，and longer WC，but lower mean HDL-C（P<0.05）．Male ratio，percent of completing high school or higher levels of education，mean DBP and CRP levels were higher in group 3 than those of group 1（P<0.05）．Analysis with unadjusted Logistic regression models showed that age，sex，hypertension history，smoking，drinking and physical exercise were associated with pre-diabetes and diabetes（P<0.05）．Moreover，analysis with adjusted Logistic regression models indicated that age，sex，hypertension history，smoking，drinking，physical exercise，BMI，and HTGWP were associated with pre-diabetes and diabetes（P<0.05）．Conclusion　HTGWP is closely related to diabetes mellitus and pre-diabetes.So increased attention should be given to lipid and WC control in priority groups to reduce the prevalence of pre-diabetes and diabetes mellitus，and the occurrence of cardiovascular events.

Key words: Prediabetic state, Diabetes mellitus, Hypertriglyceridemia, Triglycerides, Waist circumference, Clinical features