关键词: 生长和发育；乳房；青春期, 早熟；耳穴疗法

Abstract: Background　At present，there are no targeted drugs for simple premature thelarche（SPT） in girls in Western medicine.Both at home and abroad，regular follow-up and dietary guidance are used as intervention means，lacking of targeted treatment measures.In traditional Chinese medicine，individualized treatment should be emphasized.Objective　To explore the effectiveness of Shuganziyin granules combined with auricular-plaster therapy for SPT in girls with Ganyuyinxu syndrome.Methods　Thirty-eight participants with SPT were recruited from Department of Pediatrics，Shanghai Jiading Hospital of Traditional Chinese Medicine from May 2016 to November 2017.They were randomized into the treatment group（21 cases） and control group（17 cases），receiving Shuganziyin granules combined with auricular-plaster therapy，Zhibaidihuang pills combined with Xiaoyao pills via the oral route，respectively.The scores of Tanner stage of breast development in girls and TCM-based Ganyuyinxu syndrome pattern differentiation scale scores before and after treatment，and clinical response were compared between the two groups.Results　Two groups showed similar scores of Tanner stage of breast development in girls and TCM-based Ganyuyinxu syndrome pattern differentiation scale before treatment（P>0.05）．After treatment，although the scores of Tanner stage of breast development in girls were still similar in both groups（P>0.05），TCM-based Ganyuyinxu syndrome pattern differentiation scale scores decreased significantly in the treatment group（P<0.05）．The treatment group demonstrated much better clinical response compared with the control group（P<0.05）．Conclusion　Auricular-plaster therapy is simple and convenient to use.Moreover，it has no side effects and the adherence to it is high in girls.Shuganziyin granules combined with auricular-plaster therapy is effective for SPT in girls with Ganyuyinxu syndrome by reducing the concomitant symptoms.

Key words: Growth and development；Breast；Puberty, precocious；Auriculotherapy