关键词: 促甲状腺激素, 妇女, 参考值, 汉族, 维吾尔族

Abstract: Background　Foreign studies report that pre-pregnancy serum thyroid stimulating hormone（TSH） is associated with an increased risk of adverse pregnancy outcomes，while TSH levels are affected by age，ethnicity，iodine nutrition，etc，so it is necessary to establish a reference range for women of childbearing age in different regions，provide basic data for the eugenics.Objective　To establish reference interval of TSH in women of childbearing age in a community of Urumqi.Methods　A total of 356 women between 18-45 years with complete information from 2 080 subjects in an epidemiological survey of thyroid diseases in a community of Urumqi in May 2013 were selected.Subjects were divided into Uygur and Han groups，which included 182 of Uygur，174 of Han.The basic data of body mass index（BMI），TSH，anti-thyroglobulin（TgAb），anti-thyroid peroxidase（TPOAb），urinary iodine，total cholesterol（TC），high density lipoprotein cholesterol（HDL-C），low density lipoprotein cholesterol（LDL-C），triglycerides（TG） were recorded.Results　The Uygur group had higher BMI and TgAb than Han group，and the levels of TC and HDL-C were lower than those of Han group（P<0.05）．The reference interval of TSH in Han and Uygur women of childbearing age were 0.86-6.47 μU/ml and 0.55-6.86 μU/ml.TSH level in Uygur group was lower than that in Han group（P<0.05）．Conclusion　The reference interval of TSH level in Han and Uygur groups are 0.86-6.47 μU/ml and 0.55-6.86 μU/ml，respectively.

Key words: Thyrotropin, Women, Reference value, Han nationality, Uygur nationality