中国全科医学 ›› 2018, Vol. 21 ›› Issue (30): 3781-3784.DOI: 10.12114/j.issn.1007-9572.2018.00.203

• 专题研究 • 上一篇    

甲巯咪唑治疗甲状腺功能亢进症后肌酸激酶升高三例报告并文献复习

程莹   

  1. 610083四川省成都市,成都军区总医院内分泌科
  • 出版日期:2018-10-20 发布日期:2018-10-20

Methimazole-induced Elevation of Serum Creatine Kinase:Report of Three Cases and Literature Review 

CHENG Ying   

  1. Department of Endocrinology,Chengdu Military General Hospital,Chengdu 610083,China
  • Published:2018-10-20 Online:2018-10-20

摘要: 甲巯咪唑(MMI)是治疗甲状腺功能亢进症的常用药物,其不良反应中过敏、白细胞计数减少、肝功能损害等常见,肌肉损害较少见,临床上易忽视。本文报道3例MMI治疗甲状腺功能亢进症过程中出现血清肌酸激酶(CK)升高的病例,并结合相关文献进行分析,探讨可能的机制,以期在使用MMI治疗甲状腺功能亢进症的过程中注意患者的相关症状,避免漏诊。

关键词: 甲状腺功能亢进症, 甲巯咪唑, 肌酸激酶

Abstract:
Methimazole(MMI) is a common anti-thyroid drug.Adverse effects such as allergy,leucopenia and hepatotoxicity associated with MMI are frequently seen,but muscle damage associated with MMI is rare.We reported three cases who suffered from elevated serum CK during MMI treatment of hyperthyroidism,and reviewed the relevant studies,and based on this,explored the possible mechanisms.All these are for increasing clinicians' awareness of the adverse reactions among hyperthyroidism patients with MMI treatment and improving the treatment regimen for better outcome.
Hyperthyroidism;Methimazole;Creatine kinase