关键词: 脑缺血发作, 短暂性；基质金属蛋白酶9；细胞外基质；血-脑脊液屏障

Abstract: Objective　To investigate the expression and clinical significance of serum matrix metalloproteinase-9 （MMP-9） in patients with subcortical ischemic vascular disease （SIVD）．Methods　This prospective study included a SIVD group consisting of 115 patients with SIVD who were treated in the Department of Neurology of Affiliated Provincial Hospital of Anhui Medical University from October 2016 to July 2017，and a control group consisting of 69 persons who underwent physical examination in the hospital during the same period and did not have abnormal findings in head MRI.General clinical data were collected，and blood total cholesterol，triglycerides，low-density lipoprotein cholesterol and high-density lipoprotein cholesterol were detected.Fazekas scores of brain white matter lesions and lacunar infarct （LI） counts were assessed on the basis of head MRI.Serum MMP-9 concentrations were detected with enzyme-linked immunosorbent assays.MMP-9 levels and brain injury levels were compared between the two groups，and the correlation between MMP-9 and brain injury was analyzed.Results　The proportions of patients with hypertension and diabetes in the SIVD group were both higher than those of the control group （P<0.05）．The serum level of MMP-9，Fazekas scores，and LI number in the SIVD group were all higher than those in the control group （P<0.05）．Serum MMP-9 levels in patients with SIVD were positively correlated with the Fazekas score and LI number （rs=0.301，rs=0.395，P<0.001）．Multivariate Logistic regression analysis showed that hypertension 〔OR=5.349，95%CI （2.449，11.685）〕，diabetes〔OR=3.008，95%CI （1.265，7.154）〕，and serum MMP-9 level 〔OR=1.014，95%CI （1.009，1.019）〕 were all independent influencing factors for SIVD （P<0.05）．Conclusion　Elevated serum MMP-9 levels may be an independent risk factor for SIVD，and serum MMP-9 levels correlated with the severity of SIVD.This study may provide new directions for the prevention and treatment of cerebrovascular disease.

Key words: Ischemic attack, transient；Matrix metalloproteinase 9；Extracellular matrix；Blood-brain barrier