关键词: 腹膜, 间皮瘤, 预后, 组织学, 临床参数

Abstract: Objective　To investigate the effect of histopathology and common clinical indices on the prognosis of patients with malignant peritoneal mesothelioma（MPeM）．Methods　This study consisted of 72 cases diagnosed with MPeM in Cangzhou Central Hospital from 2012 to 2015.Patient data including gender，age，BMI，pathological type，TNM stage，Eastern Cooperative Oncology Group（ECOG） score，Charlsoncomorbidity index（CCI） and peritoneal carcinoma index（PCI） were obtained，and the associations between these indices and patients prognosis were analyzed.Results MPeM lacks specific clinical manifestations.In this cohort，bloat was a common symptom followed by abdominal pain.Fifty-two cases had stage Ⅰ-Ⅱ and 20 cases had stage Ⅲ-Ⅳ disease.Sixty-eight cases had diffuse MPeM and four cases had localized MPeM.With regard to pathological type，69 cases had epithelial carcinoma and 3 cases had sarcomatoid mesothelioma.Forty-two patients received intra-peritoneal chemotherapy.Histopathological type，TNM stage，ECOG score，PCI and whether undergoing chemotherapy were significantly associated with cumulative survival（P<0.05）．Cox regression analysis showed that TNM stage 〔hazard ratio（HR）=2.105，P=0.015〕，ECOG score（HR=1.930，P=0.038），and chemotherapy（HR=0.457，P=0.005） were independent prognostic factors for MPeM.Conclusion　MPeM patients in the earlier stages with better performance status have a better prognosis.Early examination and diagnosis are of great significance for improving the survival of MPeM patients.

Key words: Peritoneum, Mesothelioma, Prognosis, Histology, Clinical parameters