关键词: 斑块, 动脉粥样硬化, 颈动脉内膜中膜厚度, 危险因素, 补体C1q

Abstract: Objective　To investigate the influencing factors of carotid atheromatous plaque（CAP） formation.　Methods　The enrolled 372 participants were part of the individuals undergoing medical examination in Peking University Third Hospital from April to December 2016.We collected their clinical data，common carotid artery intima-media thickness（IMT）detected by color Doppler flow imaging〔110 were found with CAP （CAP group） and 262 without （non-CAP group）〕and measurement results of complement C1q and biochemical parameters.A multivariate Logistic regression analysis was performed to analyze the influencing factors of CAP formation.Results　Two groups had significant differences in the distribution of sex，age，smoking，regular exercise，history of hypertension and diabetes，use of antihypertensive drugs，lipid-lowering drugs and hypoglycemic agents，levels of systolic and diastolic blood pressure，body mass index，complement C1q，alanine aminotransferase，aspartate aminotransferase，urea nitrogen，uric acid，creatinine （Cr），triglyceride （TG），fasting blood glucose，high-density lipoprotein cholesterol，C-reactive protein，glycosylated hemoglobin，and homocysteine （P<0.05）.There was no correlation between bilateral IMT and complement C1q levels （rs=-0.14，P=0.052）.Multivariate Logistic regression analysis showed that age〔OR=1.11，95%CI （1.07，1.16）〕，regular exercise〔OR=2.88，95%CI （1.37，6.22）〕，use of hypoglycemic agents〔OR=0.15，95%CI （0.03，0.59）〕，diastolic blood pressure〔OR=1.05，95%CI （1.02，1.09）〕，Cr〔OR=1.03，95%CI （1.00，1.06）〕，and TG〔OR=1.49，95%CI （1.01，2.22）〕were the influencing factors of CAP formation （P<0.05）.Conclusion　CAP formation was found to be correlated with age，regular exercise，use of hypoglycemic agents，levels of blood pressure and blood lipid.This result provides an important reference for clinical prevention of CAP formation.

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