关键词: 帕金森病, 药物疗法, 多巴胺药

Abstract: Background　There are few reports regarding the initial pharmacotherapy for newly-diagnosed Parkinson's disease（PD） patients in China.Objective　To understand the current status of pharmacotherapy for PD patients by investigating the choice of initial drugs for PD patients.Methods　One hundred fifty-six patients who were initially hospitalized in Anhui Provincial Hospital Affiliated to Medical University of Anhui between September 2015 and April 2017 were selected as study subjects.Patient gender，age of disease onset，symptoms，time from disease onset to definite diagnosis，initial drugs，and drug types were collected and analyzed.Results　The initial drugs chosen by the patients included the following：levodopa（LD） alone（n=92）；LD plus dopamine agonist（DA）（LD+DA，n=30）；LD plus other anti-PD drugs（LD+X，n=3）；DA plus other anti-PD drugs（DA+X，n=23）；and non-LD/non-DA drugs（n=8）．Gender，age of disease onset，and disease symptoms did not affect patient choice for initial drugs（P>0.05），while time from disease onset to definite diagnosis did not significantly affect choice for initial drugs（P<0.05）．Conclusion　LD is a first-choice drug for most PD patients.Patients who initially use DA，monoamine oxidase inhibitors，and other anti-PD drugs are relatively fewer in number.

Key words: Parkinson disease, Drug therapy, Dopamine agents