关键词: 骨软化症, 脂肪瘤, 低磷血症

Abstract: Tumor-induced osteomalacia（TIO） is a rare paraneoplastic syndrome in the clinic setting.TIO is caused by excessive phosphorus excretion induced by the tumor，and is thus categorized as an acquired hypophosphatemic osteomalacia.TIO has an occult onset and is associated with a high rate of misdiagnosis，although TIO has some typical clinical features，such as amyosthenia，progressive ostealgia，and loss of height.Practitioners should have increased awareness of TIO.Early diagnosis，correctly positioning of the tumor，and surgical resection can achieve good outcomes.For those patients suspected to have TIO，a thorough physical examination combined with laboratory testing and imaging are sufficient for the detection and positioning of the tumor.We report herein a patient who was diagnosed with TIO and successfully treated.The relevant literature is reviewed to improve the knowledge of the disease and provide reference for clinical work.

Key words: Osteomalacia, Lipoma, Hypophosphatemia