关键词: 抗Jo-1抗体综合征, 症状和体征, 诊断

Abstract: Anti-Jo-1 antibody syndrome is a rare chronic autoimmune disorder associated with diverse clinical manifestations.The pathogenesis of this disease is unknown.Lack of understanding of the disease and misinterpretation of symptoms can lead to misdiagnosis，and opportunities for treatment and support would be delayed，which in turn deteriorates the prognosis.We reported two patients with anti-Jo-1 antibody syndrome and reviewed the recent developments in the clinical features，pathogenesis，diagnosis and treatment of anti-Jo-1 antibody syndrome in order to improve the outcome and decrease the mortality of such patients by reducing the probabilities of missed diagnosis and misdiagnosis via enhancing clinicians' understanding of the disease.

Key words: Anti-Jo-1 syndrome；Symptoms &, signs；Diagnosis