关键词: 新型冠状病毒肺炎, SARS-CoV-2, 自然感染, 血清抗体阳性率

Abstract: COVID-19 has spread to more than 220 countries and regions in the world，becoming a global pandemic. Serological testing of specific antibodies against SARS-CoV-2 can estimate the status of infection in the population，and help retrospectively assess the scale or degree of infection in the study population. This article reviews the SARS-CoV-2-specific antibody responses in naturally infected general population worldwide，and special populations such as medical workers，children，and pregnant women，aiming to provide important information for better understanding of SARS-CoV-2-specific serological features and patterns in populations in times of COVID-19，and for enhanced perception and containment of COVID-19. It has been found that the seroprevalence of SARS-CoV-2 antibodies reported globally for natural infections varies in different countries or regions，ranging from less than 0.1% to more than 20%，which may be associated with the differences in serological testing methods，and stages of COVID-19 pandemic during which the testing is performed. The seropositivity rate of children is lower than that of other age groups. But the seropositivity rate of medical workers or pregnant women is similar to that of the general population. To estimate the burden caused by COVID-19 and offer scientific evidence for the containment of the disease，it is essential to continuously carry out seroprevalence surveillance for SARS-CoV-2.

Key words: COVID-19, SARS-CoV-2, Natural infection, Seroprevalence of antibody