关键词: 糖尿病, 心血管疾病, 肠促胰素, 胰高血糖素样肽1, 二肽基肽酶4

Abstract: As a high-risk group of atherosclerotic cardiovascular disease（ASCVD），there is a growing demand for medications in patients with diabetes mellitus that could both reduce blood glucose as well as the prevalence of ASCVD，or at least may not increase it.In view of the presence of glucagon-like peptide 1 receptor（GLP-1R） on the cardiac myocytes，incretin mimetic drugs may play a role in ASCVD of diabetic patients.To explore the effect of incretin mimetic drugs on ASCVD in diabetic patients，this article systematically reviews previous published literatures at home and abroad to introduce the structure and function of incretin，and the effect of incretin on cardiac myocytes，cardiac function，blood pressure and blood lipid level.We hope to provide basis for further research and development of drugs that not only reduce blood glucose but also protect cardiovascular system，and ultimately improve the therapeutic effect and prognosis of diabetic patients，especially those with ASCVD.

Key words: Diabetes mellitus, Cardiovascular diseases, Incretin, Glucagon-like peptide 1, Dipeptidyl peptidase 4